Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study
Lu KC, Shen MC, Wang RL, Chen WW, Chiu SH, Kao YH, Liu FC, Hsiao PJ. · International journal of medical sciences. 2024;21(12):2390-2401.
Study at a glance
Human
Thirty adults with chronic stable inflammatory/metabolic conditions recruited from an outpatient department.
Oral solid H₂ capsules for 28 days: low dose 1 capsule each morning; medium dose 3 capsules each morning; high dose 3 capsules morning and 3 evening. · The clinical intervention used capsules, not H₂-rich water. The article separately prepared 1,200 ppb H₂-rich water for an in-vitro comparison; that concentration was not the participants’ administered dose.
28 days (4 weeks).
Article-reported result excerpt (24 words maximum): “Results: Compared to HRW and CaH_2, OSHCs demonstrated a prolonged reduction in ORP for 60 minutes in vitro and enabled a regulated release of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Human interventional or observational study
Oral and dental health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Thirty adults with chronic stable inflammatory/metabolic conditions recruited from an outpatient department.
30 participants; low-, medium- and high-dose groups of 10 participants each.
28 days (4 weeks).
Oral solid H₂ capsules for 28 days: low dose 1 capsule each morning; medium dose 3 capsules each morning; high dose 3 capsules morning and 3 evening.
H₂ dissolved in drinking water plus an oral H₂-generating preparation — H₂ only unless the full text explicitly reports oxygen co-delivery.
The clinical intervention used capsules, not H₂-rich water. The article separately prepared 1,200 ppb H₂-rich water for an in-vitro comparison; that concentration was not the participants’ administered dose.
Three non-randomized capsule-dose groups; the laboratory comparison also examined H₂-rich water and calcium hydride.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “Results: Compared to HRW and CaH_2, OSHCs demonstrated a prolonged reduction in ORP for 60 minutes in vitro and enabled a regulated release of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this oral and dental health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39310256 · DOI: 10.7150/ijms.101114
A free full article is available through PubMed Central.
Official PubMed/PMC full article; record re-audited and corrected 25 August 2026.
25 August 2026
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