Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study
Lu KC, Shen MC, Wang RL, Chen WW, Chiu SH, Kao YH, Liu FC, Hsiao PJ. · International journal of medical sciences. 2024;21(12):2390-2401.
What kind of evidence is this?
Human
Human interventional or observational study
Oral and dental health
H₂-rich water
Not reported in this record.
Not reported in this record.
Methods at a glance
Human participants studied for oral and dental health; aged 20 years. See eligibility criteria in the linked full text.
Human study; the full text reports 30 patients, with group/assay counts including n=10.
28 days
Full text reports H₂ dissolved in drinking water plus an oral H₂-generating preparation. Detected intervention quantities or schedules: 200 ppb, 28 days, 4 weeks, 100%, 10 μm.
H₂ dissolved in drinking water plus an oral H₂-generating preparation — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 200 ppb, 28 days, 4 weeks, 100%, 10 μm. Values are not combined across different experimental arms.
Not applicable — no inhaled H₂ intervention was identified in the full article.
No inhaled O₂ co-delivery was identified for this non-inhalation intervention.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “Results: Compared to HRW and CaH_2, OSHCs demonstrated a prolonged reduction in ORP for 60 minutes in vitro and enabled a regulated release of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this oral and dental health article.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 39310256 · DOI: 10.7150/ijms.101114
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10