Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats
Ito M, Hirayama M, Yamai K, Goto S, Ito M, Ichihara M, Ohno K. · Medical gas research. 2012;2(1):15.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Parkinson’s disease
H₂-rich water
Not reported in this record.
Not reported in this record.
Methods at a glance
rats, rat, cells used to study parkinson’s disease.
Preclinical study; group or assay counts reported in the full text include n=5, n=8, n=28, n=37, n=9, n=3.
30 min
Full text reports H₂-containing gas exposure plus H₂ dissolved in drinking water. Detected intervention quantities or schedules: 1.6 ppm, 0.8 mM, 30 min, 200 ml, 1 ml, 2 ml, 100 ml, 1.2 ppm.
Molecular H₂ gas exposure; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 1.6 ppm, 0.8 mM, 30 min, 200 ml, 1 ml, 2 ml, 100 ml, 1.2 ppm. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, inflammation and cytokines, oxidative-stress and antioxidant markers, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “PD patients ( n = 37) also showed similar increases of breath hydrogen concentrations, but the average increases were about half of the healthy…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies to the reported animal, cell or tissue model, not directly to patients.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 22608009 · DOI: 10.1186/2045-9912-2-15
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10