Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats
Ito M, Hirayama M, Yamai K, Goto S, Ito M, Ichihara M, Ohno K. · Medical gas research. 2012;2(1):15.
Study at a glance
Preclinical
rats, rat, cells used to study parkinson’s disease.
Full text reports H₂-containing gas exposure plus H₂ dissolved in drinking water. Detected intervention quantities or schedules: 1.6 ppm, 0.8 mM, 30 min, 200 ml, 1 ml, 2 ml, 100 ml, 1.2 ppm. · H₂-related quantities reported in the intervention passages: 1.6 ppm, 0.8 mM, 30 min, 200 ml, 1 ml, 2 ml, 100 ml, 1.2 ppm. Values are not combined across different experimental arms.
30 min
Article-reported result excerpt (24 words maximum): “PD patients ( n = 37) also showed similar increases of breath hydrogen concentrations, but the average increases were about half of the healthy…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Parkinson’s disease
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, rat, cells used to study parkinson’s disease.
Preclinical study; group or assay counts reported in the full text include n=5, n=8, n=28, n=37, n=9, n=3.
30 min
Full text reports H₂-containing gas exposure plus H₂ dissolved in drinking water. Detected intervention quantities or schedules: 1.6 ppm, 0.8 mM, 30 min, 200 ml, 1 ml, 2 ml, 100 ml, 1.2 ppm.
Molecular H₂ gas exposure; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 1.6 ppm, 0.8 mM, 30 min, 200 ml, 1 ml, 2 ml, 100 ml, 1.2 ppm. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, inflammation and cytokines, oxidative-stress and antioxidant markers, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “PD patients ( n = 37) also showed similar increases of breath hydrogen concentrations, but the average increases were about half of the healthy…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 22608009 · DOI: 10.1186/2045-9912-2-15
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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