Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells
Iio A, Ito M, Itoh T, Terazawa R, Fujita Y, Nozawa Y, Ohsawa I, Ohno K, Ito M. · Medical gas research. 2013;3(1):6.
Study at a glance
Preclinical
cell, cells, rabbit used to study metabolic and lipid health.
Full text reports another explicitly administered H₂ intervention. Detected intervention quantities or schedules: 0.67%, 1.0 mM, 0.1%, 15 min, 0.3 mM, 120 min, 75%, 20%, 5%, 95%. · H₂-related quantities reported in the intervention passages: 0.67%, 1.0 mM, 0.1%, 15 min, 0.3 mM, 120 min, 75%, 20%, 5%, 95%. Values are not combined across different experimental arms.
15 min
Article-reported result excerpt (24 words maximum): “Hydrogen treatment did not affect cell viability (Figure [1]) and morphology (data not shown).” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Metabolic and lipid health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
cell, cells, rabbit used to study metabolic and lipid health.
Preclinical study; group or assay counts reported in the full text include n=6.
15 min
Full text reports another explicitly administered H₂ intervention. Detected intervention quantities or schedules: 0.67%, 1.0 mM, 0.1%, 15 min, 0.3 mM, 120 min, 75%, 20%, 5%, 95%.
another explicitly administered H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.67%, 1.0 mM, 0.1%, 15 min, 0.3 mM, 120 min, 75%, 20%, 5%, 95%. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “Hydrogen treatment did not affect cell viability (Figure [1]) and morphology (data not shown).” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 23448206 · DOI: 10.1186/2045-9912-3-6
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.