Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice
Liu Q, Li BS, Song YJ, Hu MG, Lu JY, Gao A, Sun XJ, Guo XM, Liu R. · Mol Med Rep. 2016;13(4):3588–3596.
Study at a glance
Preclinical
Rats with bile-duct ligation-induced obstructive jaundice.
Hydrogen-rich saline administered after model induction. · The checked methods describe preparation and dosing.
Article-specific postoperative protocol.
Several biochemical, inflammatory, apoptotic and histologic outcomes favored hydrogen-rich saline versus untreated obstruction.
Animal-model evidence only.
What kind of evidence is this?
Preclinical
Controlled mouse study
Liver health
Other forms
Positive preclinical signal.
Biochemical and tissue outcomes in an animal model.
Methods
Rats with bile-duct ligation-induced obstructive jaundice.
Experimental group counts were checked in the full article.
Article-specific postoperative protocol.
Hydrogen-rich saline administered after model induction.
H₂ dissolved in saline.
The checked methods describe preparation and dosing.
Sham and untreated obstructive-jaundice groups.
Outcomes and reported result
Liver enzymes, oxidative and inflammatory markers, apoptosis and liver histology.
Several biochemical, inflammatory, apoptotic and histologic outcomes favored hydrogen-rich saline versus untreated obstruction.
The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Animal-model evidence only.
The reported rat obstructive-jaundice model only.
SYRCLE animal-study tool — preliminary
Some concerns
Control groups were present, but randomization, concealment and assessor blinding were incompletely reported.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 26936224 · DOI: 10.3892/mmr.2016.4954
A free publisher or repository full article was checked.
Publisher or repository full article and bibliographic record; checked 10 August 2026.
10 August 2026
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