Hydrogenology editorial study record

Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice

Liu Q, Li BS, Song YJ, Hu MG, Lu JY, Gao A, Sun XJ, Guo XM, Liu R. · Mol Med Rep. 2016;13(4):3588–3596.

PreclinicalOther formsPublished 2016

Study record, not medical adviceThis page reports one source and Hydrogenology’s source-text extraction. It does not establish that molecular hydrogen is effective, safe or appropriate for any person. Human, animal and laboratory evidence must not be treated as equivalent.

Source and classification

What kind of evidence is this?

Evidence stream

Preclinical

Reported design

Controlled mouse study

Research topic

Liver health

Administration classification

Other forms

Study result signal

Positive preclinical signal.

Outcome type

Biochemical and tissue outcomes in an animal model.

Reported in the source

Methods at a glance

Population or model

Rats with bile-duct ligation-induced obstructive jaundice.

Sample

Experimental group counts were checked in the full article.

Duration

Article-specific postoperative protocol.

Intervention

Hydrogen-rich saline administered after model induction.

Hydrogen form

H₂ dissolved in saline.

H₂ specification

The checked methods describe preparation and dosing.

H₂ flow

Not applicable.

O₂ delivered with H₂

No oxygen was co-delivered.

Comparator

Sham and untreated obstructive-jaundice groups.

Reported, not endorsed

Outcomes and reported result

Outcomes measured

Liver enzymes, oxidative and inflammatory markers, apoptosis and liver histology.

Reported result

Several biochemical, inflammatory, apoptotic and histologic outcomes favored hydrogen-rich saline versus untreated obstruction.

Results-extraction completeness

The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.

A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.

Interpretation limits

Cautions and applicability

Design and reporting cautions

Animal-model evidence only.

Applies directly to

The reported rat obstructive-jaundice model only.

Preliminary appraisal framework

SYRCLE animal-study tool — preliminary

Preliminary risk-of-bias status

Some concerns

Appraisal rationale

Control groups were present, but randomization, concealment and assessor blinding were incompletely reported.

Appraisal domains

Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified

No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.

Provenance

Sources and record status

Identifiers

PMID: 26936224 · DOI: 10.3892/mmr.2016.4954

Publisher access

A free publisher or repository full article was checked.

Extraction basis

Publisher or repository full article and bibliographic record; checked 10 August 2026.

Record revision

2026-08-10

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