Hydrogen Flush After Cold Storage as a New End‐Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury
Tamaki I, Hata K, Okamura Y, Nigmet Y, Hirao H, Kubota T, Inamoto O, Kusakabe J, Goto T, Tajima T, Yoshikawa J, Tanaka H, Tsuruyama T, Tolba RH, Uemoto S. · Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2018;24(11):1589-1602.
Study at a glance
Preclinical
rats, tissues, rat, tissue used to study cardiovascular and circulatory health.
Full text reports another explicitly administered H₂ intervention. Detected intervention quantities or schedules: 10 mm, 50 mm, 95%, 5%, 500 mm, 120 minutes, 150 mL, 2%, 4%, 1.0 ppm. · H₂-related quantities reported in the intervention passages: 10 mm, 50 mm, 95%, 5%, 500 mm, 120 minutes, 150 mL, 2%, 4%, 1.0 ppm. Values are not combined across different experimental arms.
120 minutes
Article-reported result excerpt (24 words maximum): “In contrast, bile production and lactate dehydrogenase leakage therein were both significantly improved in HyFACS‐HA and ‐PV + HA ( P < 0.01), representing…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, tissues, rat, tissue used to study cardiovascular and circulatory health.
Preclinical study; group or assay counts reported in the full text include n=10.
120 minutes
Full text reports another explicitly administered H₂ intervention. Detected intervention quantities or schedules: 10 mm, 50 mm, 95%, 5%, 500 mm, 120 minutes, 150 mL, 2%, 4%, 1.0 ppm.
another explicitly administered H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 10 mm, 50 mm, 95%, 5%, 500 mm, 120 minutes, 150 mL, 2%, 4%, 1.0 ppm. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “In contrast, bile production and lactate dehydrogenase leakage therein were both significantly improved in HyFACS‐HA and ‐PV + HA ( P < 0.01), representing…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 30120877 · DOI: 10.1002/lt.25326
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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