Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p -Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver
Yao HT, Yang YH, Li ML. · Molecules (Basel, Switzerland). 2019;24(14):E2627.
Study at a glance
Preclinical
rat, rats, tissues, tissue used to study metabolic and lipid health.
Full text reports H₂ dissolved in drinking water. No numeric quantity is inferred beyond the source wording. · The full article describes the H₂ intervention but does not report a numeric H₂ concentration.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “After that, the H_2 concentration in water gradually decreased over time.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Metabolic and lipid health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rat, rats, tissues, tissue used to study metabolic and lipid health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water. No numeric quantity is inferred beyond the source wording.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
The full article describes the H₂ intervention but does not report a numeric H₂ concentration.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “After that, the H_2 concentration in water gradually decreased over time.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 31330936 · DOI: 10.3390/molecules24142627
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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