Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs
Kobayashi E, Sano M. · PloS one. 2019;14(10):e0222863.
Study at a glance
Preclinical
pigs used to study kidney and urinary health.
Full text reports an injected or infused H₂ intervention. Detected intervention quantities or schedules: 5 minutes, 4 hours. · H₂-related quantities reported in the intervention passages: 5 minutes, 4 hours. Values are not combined across different experimental arms.
5 minutes
Article-reported result excerpt (24 words maximum): “On the other hand, after kidney storage in hydrogen gas-containing preservation solution for either 1 hour or 4 hours, blood flow was detected in…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Kidney and urinary health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
pigs used to study kidney and urinary health.
Preclinical study; the full text reports 9 animals, with group/assay counts including n=3, n=1.
5 minutes
Full text reports an injected or infused H₂ intervention. Detected intervention quantities or schedules: 5 minutes, 4 hours.
an injected or infused H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 5 minutes, 4 hours. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “On the other hand, after kidney storage in hydrogen gas-containing preservation solution for either 1 hour or 4 hours, blood flow was detected in…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 31574107 · DOI: 10.1371/journal.pone.0222863
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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