Aerosol inhalation of a hydrogen-rich solution restored septic renal function
Yao W, Guo A, Han X, Wu S, Chen C, Luo C, Li H, Li S, Hei Z. · Aging. 2019;11(24):12097-12113.
Study at a glance
Preclinical
mice, cell, cells, mouse used to study kidney and urinary health.
Full text reports inhaled H₂-containing gas plus H₂ dissolved in another reported solution. Detected intervention quantities or schedules: 0.6 mmol/L, 10 mL/kg, 24 hours, 15 days, 1 mL. · H₂-related quantities reported in the intervention passages: 0.6 mmol/L, 10 mL/kg, 24 hours, 15 days, 1 mL. Values are not combined across different experimental arms.
24 hours
Article-reported result excerpt (24 words maximum): “Moreover, fluorescent staining with ghostpen cyclopeptide revealed that the hydrogen-rich medium increased the capture ability of macrophages by enhancing the extensibility of their pseudopods…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Kidney and urinary health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, cell, cells, mouse used to study kidney and urinary health.
Preclinical study; the full text reports 6 mice, with group/assay counts including n=3, n=6, n=12, n=4, n=8.
24 hours
Full text reports inhaled H₂-containing gas plus H₂ dissolved in another reported solution. Detected intervention quantities or schedules: 0.6 mmol/L, 10 mL/kg, 24 hours, 15 days, 1 mL.
Inhaled molecular H₂; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 0.6 mmol/L, 10 mL/kg, 24 hours, 15 days, 1 mL. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “Moreover, fluorescent staining with ghostpen cyclopeptide revealed that the hydrogen-rich medium increased the capture ability of macrophages by enhancing the extensibility of their pseudopods…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 31841441 · DOI: 10.18632/aging.102542
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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