The Preventive Role of Hydrogen-Rich Water in Thioacetamide-Induced Cholangiofibrosis in Rat Assessed by Automated Histological Classification
Li C, Zhao X, Gu X, Chen Y, Yu G. · Frontiers in pharmacology. 2021;12:632045.
Study at a glance
Preclinical
rats, tissue, tissues used to study liver health.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 2 ml, 5 months, 8 weeks. · H₂-related quantities reported in the intervention passages: 2 ml, 5 months, 8 weeks. Values are not combined across different experimental arms.
5 months
Article-reported result excerpt (24 words maximum): “9 months use of H_2-rich water did not cause any pathological changes of internal organs including heart, liver and kidney compared with the control…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Liver health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, tissue, tissues used to study liver health.
Preclinical study; group or assay counts reported in the full text include n=19.
5 months
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 2 ml, 5 months, 8 weeks.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 2 ml, 5 months, 8 weeks. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “9 months use of H_2-rich water did not cause any pathological changes of internal organs including heart, liver and kidney compared with the control…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 34489690 · DOI: 10.3389/fphar.2021.632045
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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