A Comparison of the Antioxidant Effects Between Hydrogen Gas Inhalation and Vitamin C Supplementation in Response to a 60-Min Treadmill Exercise in Rat Gastrocnemius Muscle
Chaoqun L, Yuqi Z, Shi Z, Zhenghui Y, Li W. · Frontiers in physiology. 2021;12:745194.
Study at a glance
Preclinical
rats, tissues, cell, rat used to study exercise and recovery.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 4%. · H₂-related quantities reported in the intervention passages: 4%. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “CE1: p < 0.05), and both hydrogen and vitamin C supplementations significantly reduced serum MDA level after exercise (CE1 and HE1 vs.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Exercise and recovery
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, tissues, cell, rat used to study exercise and recovery.
Preclinical study; group or assay counts reported in the full text include n=8, n=9.
Multiple article-specific time points; see the linked full methods.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 4%.
Inhaled molecular H₂ at 4%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 4%. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, histology or tissue damage, metabolic laboratory measures, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “CE1: p < 0.05), and both hydrogen and vitamin C supplementations significantly reduced serum MDA level after exercise (CE1 and HE1 vs.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 34721070 · DOI: 10.3389/fphys.2021.745194
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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