The Role of Hyperthermia in Methamphetamine-Induced Depression-Like Behaviors: Protective Effects of Coral Calcium Hydride.
Wang X, Tong B, Hui R, Hou C, Zhang Z, Zhang L, Xie B, Ni Z, Cong B, Ma C, Wen D. · Frontiers in Molecular Neuroscience. 2021;14:808807.
Study at a glance
Preclinical
Male mice in methamphetamine hyperthermia and depression-like behavior models.
Coral calcium hydride, 100 or 200 mg/kg by gavage, before or after methamphetamine depending on experiment. · The product combines coral calcium and hydrogen generation; the article included coral-calcium controls in selected experiments.
Acute and repeated schedules varied by experiment.
The higher dose affected hyperthermia and both tested doses affected selected depression-like behavior measures; locomotion was not improved.
Preclinical behavioral models do not establish an antidepressant effect in people; product components and hydrogen generation are not fully separable.
What kind of evidence is this?
Preclinical
Controlled mouse experiments
Sleep and mood research
Other forms
Mixed positive preclinical signal.
Animal functional behavior and biomarker outcomes.
Methods
Male mice in methamphetamine hyperthermia and depression-like behavior models.
390 mice distributed across multiple experiments.
Acute and repeated schedules varied by experiment.
Coral calcium hydride, 100 or 200 mg/kg by gavage, before or after methamphetamine depending on experiment.
Hydrogen generated from coral calcium hydride; not Brown's gas.
The product combines coral calcium and hydrogen generation; the article included coral-calcium controls in selected experiments.
Vehicle, methamphetamine and coral-calcium controls as reported by experiment.
Outcomes and reported result
Body temperature, tail-suspension and forced-swim behavior, locomotion and molecular markers.
The higher dose affected hyperthermia and both tested doses affected selected depression-like behavior measures; locomotion was not improved.
The full article, all experimental methods, behavioral outcomes and null locomotor finding were checked.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical behavioral models do not establish an antidepressant effect in people; product components and hydrogen generation are not fully separable.
The reported methamphetamine mouse models.
SYRCLE animal-study tool — preliminary
Some concerns
Many experiments were reported, but concealment and outcome-assessor blinding were not consistently established.
Randomization/allocation reporting is limited · Blinding of personnel is unclear · Attrition is incompletely reported in places · Blinding of outcome assessors is unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 35058751 · DOI: 10.3389/fnmol.2021.808807
Free full article in PubMed Central.
PubMed record and PubMed Central full text; extraction checked 9 August 2026.
10 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.