Development of a novel porcine ischemia/reperfusion model inducing different ischemia times in bilateral kidneys-effects of hydrogen gas inhalation
Kinoshita Y, Shirakawa K, Sano M, Yokoo T, Kume H, Kobayashi E. · Translational andrology and urology. 2022;11(4):430-438.
Study at a glance
Preclinical
pigs, cell used to study kidney and urinary health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 100%, 250 mL/min, 5%, 3.0 L/min, 3%, 10 min, 30 min, 8.3%, 9.9%. · H₂-related quantities reported in the intervention passages: 100%, 250 mL/min, 5%, 3.0 L/min, 3%, 10 min, 30 min, 8.3%, 9.9%. Values are not combined across different experimental arms.
250 mL/min
Article-reported result excerpt (24 words maximum): “The mean increase in plasma DNA levels released from the kidneys by IRI (difference between post-IRI renal vein level and pre-IRI inferior vena cava…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Kidney and urinary health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
pigs, cell used to study kidney and urinary health.
Preclinical study; group or assay counts reported in the full text include n=2.
250 mL/min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 100%, 250 mL/min, 5%, 3.0 L/min, 3%, 10 min, 30 min, 8.3%, 9.9%.
Inhaled molecular H₂; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 100%, 250 mL/min, 5%, 3.0 L/min, 3%, 10 min, 30 min, 8.3%, 9.9%. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, cardiovascular measures
Article-reported result excerpt (24 words maximum): “The mean increase in plasma DNA levels released from the kidneys by IRI (difference between post-IRI renal vein level and pre-IRI inferior vena cava…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 35558259 · DOI: 10.21037/tau-21-1164
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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