Effects of pre-exercise H_2 inhalation on physical fatigue and related prefrontal cortex activation during and after high-intensity exercise
Hong Y, Dong G, Li Q, Wang V, Liu M, Jiang G, Bao D, Zhou J. · Frontiers in physiology. 2022;13:988028.
Study at a glance
Human
Human participants studied for exercise and recovery; age 18–35 years. See eligibility criteria in the linked full text.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 20 min, 2 min, 21.57%, 4.08%, 1800 ml/min, 0%, 25%, 50%, 75%. · H₂-related quantities reported in the intervention passages: 20 min, 2 min, 21.57%, 4.08%, 1800 ml/min, 0%, 25%, 50%, 75%. Values are not combined across different experimental arms.
20 min
Article-reported result excerpt (24 words maximum): “No significant differences in RPE, HR and fNIRS outcomes at baseline were observed between PLAC and H_2 gas inhalation ( p > 0.131), but…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Human
Human interventional or observational study
Exercise and recovery
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for exercise and recovery; age 18–35 years. See eligibility criteria in the linked full text.
Human study; the full text reports 24 participants, with group/assay counts including n=24.
20 min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 20 min, 2 min, 21.57%, 4.08%, 1800 ml/min, 0%, 25%, 50%, 75%.
Inhaled molecular H₂; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 20 min, 2 min, 21.57%, 4.08%, 1800 ml/min, 0%, 25%, 50%, 75%. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Placebo or matched control reported in the full article.
Outcomes and reported result
clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, neurological or behavioral measures, cardiovascular measures, respiratory measures
Article-reported result excerpt (24 words maximum): “No significant differences in RPE, HR and fNIRS outcomes at baseline were observed between PLAC and H_2 gas inhalation ( p > 0.131), but…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies only to the population and protocol reported in this exercise and recovery article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36117685 · DOI: 10.3389/fphys.2022.988028
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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