Effects of pre-exercise H_2 inhalation on physical fatigue and related prefrontal cortex activation during and after high-intensity exercise
Hong Y, Dong G, Li Q, Wang V, Liu M, Jiang G, Bao D, Zhou J. · Frontiers in physiology. 2022;13:988028.
What kind of evidence is this?
Human
Human interventional or observational study
Exercise and recovery
Inhaled H₂
Not reported in this record.
Not reported in this record.
Methods at a glance
Human participants studied for exercise and recovery; age 18–35 years. See eligibility criteria in the linked full text.
Human study; the full text reports 24 participants, with group/assay counts including n=24.
20 min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 20 min, 2 min, 21.57%, 4.08%, 1800 ml/min, 0%, 25%, 50%, 75%.
Inhaled molecular H₂; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 20 min, 2 min, 21.57%, 4.08%, 1800 ml/min, 0%, 25%, 50%, 75%. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Placebo or matched control reported in the full article.
Outcomes and reported result
clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, neurological or behavioral measures, cardiovascular measures, respiratory measures
Article-reported result excerpt (24 words maximum): “No significant differences in RPE, HR and fNIRS outcomes at baseline were observed between PLAC and H_2 gas inhalation ( p > 0.131), but…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies only to the population and protocol reported in this exercise and recovery article.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 36117685 · DOI: 10.3389/fphys.2022.988028
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10