The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q_10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease
Sumbalová Z, Kucharská J, Rausová Z, Gvozdjáková A, Szántová M, Kura B, Mojto V, Slezák J. · International journal of molecular sciences. 2023;24(15):12477.
What kind of evidence is this?
Human
Randomized blinded controlled study
Exercise and recovery
H₂-rich water
Not reported in this record.
Not reported in this record.
Methods at a glance
Human participants studied for exercise and recovery. See eligibility criteria in the linked full text.
Human study; the full text reports 30 patients, with group/assay counts including n=57.
8 weeks
Full text reports H₂ dissolved in drinking water plus H₂ dissolved in saline. Detected intervention quantities or schedules: 330 mL, 8 weeks.
H₂ dissolved in drinking water plus H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 330 mL, 8 weeks. Values are not combined across different experimental arms.
Not applicable — no inhaled H₂ intervention was identified in the full article.
No inhaled O₂ co-delivery was identified for this non-inhalation intervention.
Placebo or matched control reported in the full article.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “In the H_2 group, this parameter was significantly lower at baseline when compared to the control group (−11.4%, p = 0.007), and it increased…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Human evidence; design, sample size and comparator limit interpretation. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies only to the population and protocol reported in this exercise and recovery article.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 37569850 · DOI: 10.3390/ijms241512477
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10