The Improvement of Physical Function and Caregiver Burden by a Multimodal Intervention: A Case Study of Combined Exercise Therapy, Nutritional Guidance, and Hydrogen Gas Inhalation Therapy
Harada Y, Okamura R, Sawano J, Koide N, Miyakawa M. · Cureus. 2025;17(2):e79516.
Study at a glance
Human
Human participants studied for exercise and recovery. See eligibility criteria in the linked full text.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 4%, 60 minutes. · H₂-related quantities reported in the intervention passages: 4%, 60 minutes. Values are not combined across different experimental arms.
60 minutes
Article-reported result excerpt (24 words maximum): “Parameters Reference Range* X - 90 days Pre-intervention Results (X day) Post-intervention Results (X+ 90 days) .” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Human
Human interventional or observational study
Exercise and recovery
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for exercise and recovery. See eligibility criteria in the linked full text.
Human study; the article does not state one consolidated sample total, so no total is inferred.
60 minutes
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 4%, 60 minutes.
Inhaled molecular H₂; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 4%, 60 minutes. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, neurological or behavioral measures, cardiovascular measures
Article-reported result excerpt (24 words maximum): “Parameters Reference Range* X - 90 days Pre-intervention Results (X day) Post-intervention Results (X+ 90 days) .” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies only to the population and protocol reported in this exercise and recovery article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 40151718 · DOI: 10.7759/cureus.79516
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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