Hydration bioanalyses of the effects of hydrogen-rich water (HRW)
Pesotskaya LA, Ignatov II, Popova TP, Huether F, Ignatov AI. · Wiad Lek. 2026;79(4):690–699.
What kind of evidence is this?
Human
Uncontrolled before-and-after study
Other molecular hydrogen research
H₂-rich water
Exploratory within-person laboratory signal.
Hydration-related laboratory and hemorheological outcomes.
Methods at a glance
Ten healthy adult volunteers.
10 participants; sex-stratified observations were reported.
21 days.
Regular consumption of Hydrogen Evodrop-rich water for 21 days.
H₂ dissolved in drinking water.
Reported dissolved H₂ concentration 0.9–1.2 ppm; the daily volume was not stated.
Not applicable — drinking water.
No oxygen was co-delivered.
Participants before the intervention; no concurrent control group.
Outcomes and reported result
Hematocrit, blood viscosity, urine osmolality and erythrocyte morphology.
The article reports changes from baseline in hematocrit, blood-viscosity measures and urine osmolality; it reports no erythrocyte agglutination or morphological abnormality.
The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Very small uncontrolled study, no clinical endpoint and no reported daily water volume. One author is a co-inventor on a related patent.
Healthy volunteers under this short protocol only.
ROBINS-I — preliminary
Serious concerns
No concurrent comparator, very small sample and multiple laboratory outcomes make the estimates highly vulnerable to confounding, time effects and selective reporting.
Selection and allocation checked · Confounding and co-interventions remain possible · Missing observations checked where reported · Outcome measurement varies by endpoint · Selective reporting cannot be excluded
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 42139605 · DOI: 10.36740/wlek/218738
A free publisher or repository full article was checked.
Publisher or repository full article and bibliographic record; checked 10 August 2026.
2026-08-10