Hydration bioanalyses of the effects of hydrogen-rich water (HRW)
Pesotskaya LA, Ignatov II, Popova TP, Huether F, Ignatov AI. · Wiad Lek. 2026;79(4):690–699.
Study at a glance
Human
Ten healthy adult volunteers.
Regular consumption of Hydrogen Evodrop-rich water for 21 days. · Reported dissolved H₂ concentration 0.9–1.2 ppm; the daily volume was not stated.
21 days.
The article reports changes from baseline in hematocrit, blood-viscosity measures and urine osmolality; it reports no erythrocyte agglutination or morphological abnormality.
Very small uncontrolled study, no clinical endpoint and no reported daily water volume. One author is a co-inventor on a related patent.
What kind of evidence is this?
Human
Uncontrolled before-and-after study
Other molecular hydrogen research
H₂-rich water
Exploratory within-person laboratory signal.
Hydration-related laboratory and hemorheological outcomes.
Methods
Ten healthy adult volunteers.
10 participants; sex-stratified observations were reported.
21 days.
Regular consumption of Hydrogen Evodrop-rich water for 21 days.
H₂ dissolved in drinking water.
Reported dissolved H₂ concentration 0.9–1.2 ppm; the daily volume was not stated.
Participants before the intervention; no concurrent control group.
Outcomes and reported result
Hematocrit, blood viscosity, urine osmolality and erythrocyte morphology.
The article reports changes from baseline in hematocrit, blood-viscosity measures and urine osmolality; it reports no erythrocyte agglutination or morphological abnormality.
The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Very small uncontrolled study, no clinical endpoint and no reported daily water volume. One author is a co-inventor on a related patent.
Healthy volunteers under this short protocol only.
ROBINS-I — preliminary
Serious concerns
No concurrent comparator, very small sample and multiple laboratory outcomes make the estimates highly vulnerable to confounding, time effects and selective reporting.
Selection and allocation checked · Confounding and co-interventions remain possible · Missing observations checked where reported · Outcome measurement varies by endpoint · Selective reporting cannot be excluded
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 42139605 · DOI: 10.36740/wlek/218738
A free publisher or repository full article was checked.
Publisher or repository full article and bibliographic record; checked 10 August 2026.
10 August 2026
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