Silicon-Based Agent Attenuates Age-Related Spermatogenesis Disorder.
Kuribayashi S, Fukuhara S, Kitakaze H, Tsujimura G, Imanaka T, Ueda N, Takezawa K, Kobayashi H, Imamura R, Nonomura N. · International Journal of Urology. 2025.
What kind of evidence is this?
Preclinical
Controlled mouse study
Other molecular hydrogen research
Other forms
Mixed positive preclinical signal.
Animal reproductive function, tissue and biomarker outcomes.
Methods at a glance
Aged male C57BL/6J mice.
The article reports aged-mouse experiments; a consolidated sample count was not clearly stated in the methods text.
Five weeks, from 85 to 90 weeks of age.
Diet containing 1.0% silicon-based hydrogen-generating agent.
Hydrogen generated in the gastrointestinal tract by a silicon-based dietary agent; not Brown's gas.
Tissue hydrogen exposure was not directly quantified.
Not applicable — dietary agent.
No oxygen was co-delivered.
Age-matched mice receiving control diet.
Outcomes and reported result
Sperm count and motility, seminiferous-tubule histology and oxidative-stress markers.
The supplemented group showed favorable changes in sperm measures, testicular histology and selected oxidative-stress measures.
The full article, methods, figures and reported outcomes were checked.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Animal evidence only, incomplete reporting of allocation/blinding and a hydrogen-generating silicon product rather than isolated H2 exposure.
Aged male mice under the reported protocol.
SYRCLE animal-study tool — preliminary
Some concerns
Group allocation and outcome-assessor blinding were not clearly established.
Randomization/allocation reporting is limited · Blinding of personnel is unclear · Attrition is incompletely reported in places · Blinding of outcome assessors is unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 40734345 · DOI: 10.1111/iju.70189
Free full article in PubMed Central.
PubMed record and PubMed Central full text; extraction checked 9 August 2026.
2026-08-10