Hydrogenology
Source-linked study record

Morphofunctional characteristics of the liver and kidneys of Chinchilla lanigera during consumption of water enriched with molecular hydrogen

Panina EV, Karkishchenko VN, Ostrenko KS, Petrov DV, Sorochan AE. · Journal Biomed. 2024;20(3E):70–76.

PreclinicalH₂-rich waterPublished 2024Source checked
Study record, not medical adviceThis record reports what the source states. It is not medical advice and does not establish that molecular hydrogen is effective, safe or appropriate for any person.
Quick summary

Study at a glance

Evidence type

Preclinical

Population or model

Chinchilla lanigera maintained under the reported laboratory conditions.

Intervention and dose

Water enriched with molecular hydrogen. · The checked article reports preparation and monitoring; see the linked full text.

Duration

Three years.

Reported result

The article reports group differences in selected liver and kidney measures after long-term exposure.

Main limitation

Small, long-duration animal study with limited reporting of randomization and blinding.

Evidence and classification

What kind of evidence is this?

Evidence type

Preclinical

Reported design

Controlled long-duration animal study

Research topic

Liver health

Administration form

H₂-rich water

Study result signal

Mixed exploratory preclinical signal.

Outcome type

Long-term organ morphology and laboratory outcomes in animals.

Reported in the source

Methods

Population or model

Chinchilla lanigera maintained under the reported laboratory conditions.

Sample

20 chinchillas.

Duration

Three years.

Intervention

Water enriched with molecular hydrogen.

Hydrogen form

H₂ dissolved in drinking water.

Dose or H₂ specification

The checked article reports preparation and monitoring; see the linked full text.

Comparator

Animals receiving standard water.

Reported, not endorsed

Outcomes and reported result

Outcomes measured

Liver and kidney morphology and functional laboratory measures.

Reported result

The article reports group differences in selected liver and kidney measures after long-term exposure.

Extraction completeness

The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.

A reported association, difference or mechanism is not automatically a clinical benefit.

Interpretation limits

Limitations and applicability

Main methodological cautions

Small, long-duration animal study with limited reporting of randomization and blinding.

Applies directly to

Chinchillas under the reported husbandry and exposure conditions.

Preliminary appraisal framework

SYRCLE animal-study tool — preliminary

Preliminary risk-of-bias status

High risk

Appraisal rationale

Allocation, handling differences, attrition and blinded assessment were not fully established.

Appraisal domains

Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified

No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.

Sources and status

Sources and record status

Identifiers

DOI: 10.33647/2713-0428-20-3E-70-76 · DOI: 10.33647/2713-0428-20-3E-70-76

Publisher access

A free publisher or repository full article was checked.

Extraction basis

Publisher or repository full article and bibliographic record; checked 10 August 2026.

Last reviewed

10 August 2026

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