Hydrogen inhalation ameliorates oxidative stress in transplantation-induced intestinal graft injury
Buchholz BM et al. · Am J Transplant. 2008;8(10):2015–2024.
Study at a glance
Preclinical
Lewis-rat intestinal donors and recipients after 3 hours of cold ischemia
Donors and recipients inhaled 2% H₂ perioperatively · 2% H₂ in air.
Perioperative exposure; principal outcomes 24 hours after transplantation
The article reports improved graft transit and contractility and lower inflammatory, oxidative, barrier-injury and remote-lung measures with H₂ inhalation.
Rat transplantation model, perioperative exposure, multiple organ outcomes and incomplete flow/sample extraction. It is not a clinical transplantation trial.
What kind of evidence is this?
Preclinical
Controlled syngeneic orthotopic small-intestinal-transplant experiment in rats
Critical care and ischemia-reperfusion
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Lewis-rat intestinal donors and recipients after 3 hours of cold ischemia
Group and total sample sizes require further extraction from the freely accessible article
Perioperative exposure; principal outcomes 24 hours after transplantation
Donors and recipients inhaled 2% H₂ perioperatively
H₂ diluted in air — not Brown’s gas.
2% H₂ in air.
Not reported — the accessible abstract gives concentration but no H₂ flow in mL/min.
O₂ was present at the ambient-air fraction; no supplemental O₂ or absolute O₂ flow was reported.
Perioperative air without added H₂
Outcomes and reported result
Gastrointestinal transit, muscle contractility, inflammatory mediators, lipid peroxidation, histology, permeability and remote-lung inflammation
The article reports improved graft transit and contractility and lower inflammatory, oxidative, barrier-injury and remote-lung measures with H₂ inhalation.
Gas concentration, model and principal results extracted; group sizes, exact chamber flow, funding and complete methods require further full-text extraction.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Rat transplantation model, perioperative exposure, multiple organ outcomes and incomplete flow/sample extraction. It is not a clinical transplantation trial.
Experimental small-intestinal transplantation in rats.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 18727697 · DOI: 10.1111/j.1600-6143.2008.02359.x
PubMed identifies a free article; stable free access is linked from the PubMed record.
PubMed abstract and linked free-article metadata.
10 August 2026
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