Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice
Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, Nakao A. · Journal of clinical biochemistry and nutrition. 2010;46(3):269-276.
Study at a glance
Preclinical
mice, mouse, cell, tissue used to study other neurological conditions.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 18 weeks, 1 mL/min, 10%, 15 min, 99.9%. · H₂-related quantities reported in the intervention passages: 18 weeks, 1 mL/min, 10%, 15 min, 99.9%. Values are not combined across different experimental arms.
18 weeks
Article-reported result excerpt (24 words maximum): “However, treatment with hydrogen water for 30 days prevented age-related declines in cognitive ability seen in SAMP8 as assessed by a water maze test…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Other neurological conditions
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, mouse, cell, tissue used to study other neurological conditions.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
18 weeks
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 18 weeks, 1 mL/min, 10%, 15 min, 99.9%.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 18 weeks, 1 mL/min, 10%, 15 min, 99.9%. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “However, treatment with hydrogen water for 30 days prevented age-related declines in cognitive ability seen in SAMP8 as assessed by a water maze test…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 20490324 · DOI: 10.3164/jcbn.10-19
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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