Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice
Chuai Y, Shen J, Qian L, Wang Y, Huang Y, Gao F, Cui J, Ni J, Zhao L, Liu S, Sun X, Li B, Cai J. · Medical science monitor : international medical journal of experimental and clinical research. 2012;18(3):BR89-94.
Study at a glance
Preclinical
mice, tissue, cell, cells used to study cancer research.
Full text reports H₂ dissolved in drinking water plus H₂ dissolved in saline. Detected intervention quantities or schedules: 0.6 mmol/L, 5 ml/kg, 5 min. · H₂-related quantities reported in the intervention passages: 0.6 mmol/L, 5 ml/kg, 5 min. Values are not combined across different experimental arms.
5 min
Article-reported result excerpt (24 words maximum): “As shown, H_2 pre-treatment significantly reduced the seminiferous epithelium injury caused by IR..” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Cancer research
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, tissue, cell, cells used to study cancer research.
Preclinical study; group or assay counts reported in the full text include n=8, n=3.
5 min
Full text reports H₂ dissolved in drinking water plus H₂ dissolved in saline. Detected intervention quantities or schedules: 0.6 mmol/L, 5 ml/kg, 5 min.
H₂ dissolved in drinking water plus H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.6 mmol/L, 5 ml/kg, 5 min. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “As shown, H_2 pre-treatment significantly reduced the seminiferous epithelium injury caused by IR..” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 22367121 · DOI: 10.12659/msm.882513
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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