Neuroprotective effect of hydrogen-rich saline in acute carbon-monoxide poisoning
Shen MH et al. · CNS Neurosci Ther. 2013;19(5):361–363.
Study at a glance
Preclinical
Rats exposed to acute carbon-monoxide poisoning
Hydrogen-rich saline 10 mL/kg intraperitoneally · Numeric dissolved-H₂ concentration is not stated in the accessible article summary.
Acute treatment and tissue assessment; exact schedule requires further extraction
The article reports more preserved neurons, lower ROS and MDA, higher SOD and favorable apoptosis measures. Glutathione-peroxidase activity and Bax did not significantly differ with H₂ treatment.
Small preclinical poisoning study with short article format and several molecular outcomes. It does not establish treatment for human carbon-monoxide poisoning.
What kind of evidence is this?
Preclinical
Controlled rat acute carbon-monoxide-poisoning experiment
Other neurological conditions
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Rats exposed to acute carbon-monoxide poisoning
Principal figures report n=6–9 per group; total animal allocation is not stated as one figure
Acute treatment and tissue assessment; exact schedule requires further extraction
Hydrogen-rich saline 10 mL/kg intraperitoneally
H₂ dissolved in saline — H₂ only, not Brown’s gas and not inhalation.
Numeric dissolved-H₂ concentration is not stated in the accessible article summary.
Carbon-monoxide-poisoned rats receiving ordinary saline and unpoisoned controls
Outcomes and reported result
Neuronal survival, ROS, MDA, SOD, glutathione peroxidase, caspases, Bcl-2 and Bax
The article reports more preserved neurons, lower ROS and MDA, higher SOD and favorable apoptosis measures. Glutathione-peroxidase activity and Bax did not significantly differ with H₂ treatment.
Dose, principal figures and positive and null results checked in the freely accessible PMC article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Small preclinical poisoning study with short article format and several molecular outcomes. It does not establish treatment for human carbon-monoxide poisoning.
Acute carbon-monoxide poisoning in rats.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 23607699 · DOI: 10.1111/cns.12094
Open-access full text is available through PMC.
Open-access PMC article and PubMed record.
10 August 2026
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