Hydrogen-rich saline ameliorates the retina against light-induced damage in rats
Tian L, Zhang L, Xia F, An J, Sugita Y, Zhang Z. · Medical gas research. 2013;3(1):19.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Eye health
H₂-rich water
Not reported in this record.
Not reported in this record.
Methods at a glance
rats, rat, tissue used to study eye health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water plus H₂ dissolved in saline. No numeric quantity is inferred beyond the source wording.
H₂ dissolved in drinking water plus H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
The full article describes the H₂ intervention but does not report a numeric H₂ concentration.
Not applicable — no inhaled H₂ intervention was identified in the full article.
No inhaled O₂ co-delivery was identified for this non-inhalation intervention.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “The changes of electroretinograph components in SD rats that were administrated with HRS before light exposure (prevention group) and after light-induced damage for the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 24004679 · DOI: 10.1186/2045-9912-3-19
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10