Saturated hydrogen saline protects rats from acute lung injury induced by paraquat
Zhang HL et al. · World J Emerg Med. 2011;2(2):149–153.
Study at a glance
Preclinical
Sprague-Dawley rats receiving oral paraquat
Saturated hydrogen saline 5 mL/kg intraperitoneally three times daily for 3 days · The article describes saturated H₂ saline; a numeric dissolved-H₂ concentration was not identified in the extracted methods.
Three treatments per day for 3 days after 50 mg/kg oral paraquat
The article reports less hypoxemia, edema, oxidative injury and histologic lung damage with saturated H₂ saline.
Small acute toxin model with only three days of follow-up and no human participants.
What kind of evidence is this?
Preclinical
Randomized three-group rat paraquat-poisoning experiment
Respiratory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Sprague-Dawley rats receiving oral paraquat
30 rats, n=10/group
Three treatments per day for 3 days after 50 mg/kg oral paraquat
Saturated hydrogen saline 5 mL/kg intraperitoneally three times daily for 3 days
H₂ dissolved in saline — H₂ only, not Brown’s gas and not inhalation.
The article describes saturated H₂ saline; a numeric dissolved-H₂ concentration was not identified in the extracted methods.
Paraquat without H₂ saline and ordinary-saline control
Outcomes and reported result
Arterial blood gas, lung wet/dry ratio, MDA, 8-OHdG and histology
The article reports less hypoxemia, edema, oxidative injury and histologic lung damage with saturated H₂ saline.
Allocation, dose, schedule, principal results and conflict statement checked in the open-access full text; numeric dissolved-H₂ concentration remains unconfirmed.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Small acute toxin model with only three days of follow-up and no human participants.
Paraquat-induced acute lung injury in rats, not clinical paraquat poisoning.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 25215001 · DOI: 10.5847/wjem.j.1920-8642.2011.02.013
Open-access full text is available through PMC.
Open-access PMC full text and PubMed record; no retraction or expression of concern was shown in the checked records on 7 August 2026.
10 August 2026
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