Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury
Dohi K, Kraemer BC, Erickson MA, McMillan PJ, Kovac A, Flachbartova Z, Hansen KM, Shah GN, Sheibani N, Salameh T, Banks WA. · PloS one. 2014;9(9):e108034.
Study at a glance
Preclinical
mice, mouse, tissue, rabbit used to study parkinson’s disease.
Full text reports another explicitly administered H₂ intervention. Detected intervention quantities or schedules: 3%, 5%, 45 minutes, 0.05%, 0.01%, 7 days, 0.1%, 1 hour, 1.6 mM, 1.8 ppm. · H₂-related quantities reported in the intervention passages: 3%, 5%, 45 minutes, 0.05%, 0.01%, 7 days, 0.1%, 1 hour, 1.6 mM, 1.8 ppm. Values are not combined across different experimental arms.
45 minutes
Article-reported result excerpt (24 words maximum): “The CCI-induced increase in AT8 and Alz50 immunoreactivity is attenuated by treatment with hydrogen water.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Parkinson’s disease
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, mouse, tissue, rabbit used to study parkinson’s disease.
Preclinical study; group or assay counts reported in the full text include n=4, n=10, n=8, n=6, n=5, n=7.
45 minutes
Full text reports another explicitly administered H₂ intervention. Detected intervention quantities or schedules: 3%, 5%, 45 minutes, 0.05%, 0.01%, 7 days, 0.1%, 1 hour, 1.6 mM, 1.8 ppm.
another explicitly administered H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 3%, 5%, 45 minutes, 0.05%, 0.01%, 7 days, 0.1%, 1 hour, 1.6 mM, 1.8 ppm. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “The CCI-induced increase in AT8 and Alz50 immunoreactivity is attenuated by treatment with hydrogen water.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 25251220 · DOI: 10.1371/journal.pone.0108034
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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