Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice
Guo J, Zhao D, Lei X, Zhao H, Yang Y, Zhang P, Liu P, Xu Y, Zhu M, Liu H, Chen Y, Chuai Y, Li B, Gao F, Cai J. · 2016.
Study at a glance
Preclinical
Mice exposed to low-dose, long-duration radiation.
Hydrogen-rich water during the radiation protocol. · Article-specific preparation and replacement schedule.
Long-term low-dose radiation protocol with behavioral and tissue testing.
Several behavioral, hematopoietic, reproductive and oxidative measures favored hydrogen water, while not every measured outcome differed.
Animal evidence only; many endpoints increase multiplicity and selective-reporting concerns.
What kind of evidence is this?
Preclinical
Controlled mouse radiation-exposure study
Critical care and ischemia-reperfusion
H₂-rich water
Mixed positive preclinical signal.
Animal behavioral, tissue and laboratory outcomes.
Methods
Mice exposed to low-dose, long-duration radiation.
80 mice across intervention and control groups.
Long-term low-dose radiation protocol with behavioral and tissue testing.
Hydrogen-rich water during the radiation protocol.
H₂ dissolved in drinking water.
Article-specific preparation and replacement schedule.
Radiation-exposed and non-exposed controls with conventional water.
Outcomes and reported result
Behavior, hematopoietic and reproductive measures, splenic lymphocytes and oxidative markers.
Several behavioral, hematopoietic, reproductive and oxidative measures favored hydrogen water, while not every measured outcome differed.
The full article was checked for methods, intervention details, outcomes, positive and null findings, funding and conflicts. This record does not imply medical efficacy.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Animal evidence only; many endpoints increase multiplicity and selective-reporting concerns.
The reported mouse radiation model only.
SYRCLE animal-study tool — preliminary
Some concerns
Controlled groups were present, but allocation concealment, assessor blinding and multiplicity handling were unclear.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 27774116 · DOI: 10.1155/2016/1947819
A free full article is available through PubMed Central.
Official PubMed Central full article and PubMed bibliographic record; source identity, methods, intervention, results, funding and conflicts checked 10 August 2026.
10 August 2026
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