Hydrogen does not exert neuroprotective effects or improve functional outcomes in rats after intracerebral hemorrhage
Takeuchi S, Nagatani K, Otani N, Wada K, Mori K. · Turk Neurosurg. 2016;26(6):854–859.
Study at a glance
Preclinical
Rats in an experimental intracerebral-hemorrhage model.
Hydrogen gas inhalation after intracerebral hemorrhage. · The checked methods report the gas exposure protocol.
Acute post-injury protocol.
The article did not find amelioration of the main intracerebral-hemorrhage outcomes with the reported H₂ protocol.
A null result in one animal model does not determine clinical effects.
What kind of evidence is this?
Preclinical
Controlled rat study
Other neurological conditions
Inhaled H₂
No clear treatment signal.
Functional, tissue and biomarker outcomes in a rat model.
Methods
Rats in an experimental intracerebral-hemorrhage model.
Animal groups and analyzed counts were checked in the article.
Acute post-injury protocol.
Hydrogen gas inhalation after intracerebral hemorrhage.
Inhaled H₂-containing gas.
The checked methods report the gas exposure protocol.
See the linked full methods for chamber delivery.
Comparator gas conditions were checked in the full article.
Hemorrhage animals without H₂ exposure and sham controls.
Outcomes and reported result
Neurological function, edema, oxidative markers and tissue injury.
The article did not find amelioration of the main intracerebral-hemorrhage outcomes with the reported H₂ protocol.
The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
A null result in one animal model does not determine clinical effects.
The reported rat hemorrhage model and protocol only.
SYRCLE animal-study tool — preliminary
Some concerns
Controlled groups were used, but sequence generation, concealment and blinded outcome assessment were not fully established.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 27801926 · DOI: 10.5137/1019-5149.jtn.14098-15.1
A free publisher or repository full article was checked.
Publisher or repository full article and bibliographic record; checked 10 August 2026.
10 August 2026
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