Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy
Yang L, Li D, Chen S. · Open medicine (Warsaw, Poland). 2016;11(1):399-406.
Study at a glance
Human
Human participants studied for cancer research. See eligibility criteria in the linked full text.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.9%, 0.6 mmol/L, 10 days, 5 mL/kg, 3 mL. · H₂-related quantities reported in the intervention passages: 0.9%, 0.6 mmol/L, 10 days, 5 mL/kg, 3 mL. Values are not combined across different experimental arms.
10 days
Article-reported result excerpt (24 words maximum): “Anterior fontanel tension, disturbance of consciousness, muscle tone, primitive reflex recovery time, and con-vulsion control time were significantly decreased in the hydrogen water treatment…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Human interventional or observational study
Cancer research
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for cancer research. See eligibility criteria in the linked full text.
Human study; group or assay counts reported in the full text include n=20.
10 days
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.9%, 0.6 mmol/L, 10 days, 5 mL/kg, 3 mL.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.9%, 0.6 mmol/L, 10 days, 5 mL/kg, 3 mL. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “Anterior fontanel tension, disturbance of consciousness, muscle tone, primitive reflex recovery time, and con-vulsion control time were significantly decreased in the hydrogen water treatment…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this cancer research article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 28352827 · DOI: 10.1515/med-2016-0072
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.