Inhaled hydrogen ameliorates endotoxin‐induced bowel dysfunction
Sakata H, Okamoto A, Aoyama-Ishikawa M, Yamashita H, Kohama K, Fujisaki N, Yamada T, Kotani J, Tsukahara K, Iida A, Nakao A. · 2017.
Study at a glance
Preclinical
Rodents with endotoxin-associated bowel dysfunction and related cell assays.
1.3% inhaled hydrogen after endotoxin exposure. · 1.3% H₂ in the reported carrier mixture.
Acute post-endotoxin protocol.
Hydrogen was reported to improve gastrointestinal transit and several barrier or inflammatory measures after endotoxin exposure.
Preclinical evidence only; multiple mechanistic endpoints and small groups.
What kind of evidence is this?
Preclinical
Controlled endotoxin animal and cell study
Gastrointestinal health
Inhaled H₂
Positive preclinical signal.
Animal gastrointestinal-function and mechanistic outcomes.
Methods
Rodents with endotoxin-associated bowel dysfunction and related cell assays.
Small animal and cell groups with assay-specific counts.
Acute post-endotoxin protocol.
1.3% inhaled hydrogen after endotoxin exposure.
Inhaled molecular H₂.
1.3% H₂ in the reported carrier mixture.
Absolute H₂ flow was not reported separately.
Carrier-gas composition was reported; no Brown's-gas classification is inferred.
Endotoxin injury without hydrogen and laboratory controls.
Outcomes and reported result
Gastrointestinal transit, barrier function, inflammation and related signaling.
Hydrogen was reported to improve gastrointestinal transit and several barrier or inflammatory measures after endotoxin exposure.
The full article was checked for methods, intervention details, outcomes, positive and null findings, funding and conflicts. This record does not imply medical efficacy.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; multiple mechanistic endpoints and small groups.
The reported endotoxin bowel-dysfunction models only.
SYRCLE animal-study tool — preliminary
Some concerns
Controls were present, but sequence generation, concealment and blinded assessment were incompletely reported.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 29123834 · DOI: 10.1002/ams2.218
A free full article is available through PubMed Central.
Official PubMed Central full article and PubMed bibliographic record; source identity, methods, intervention, results, funding and conflicts checked 10 August 2026.
10 August 2026
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