Effect of H_2 treatment in a mouse model of rheumatoid arthritis‐associated interstitial lung disease
Terasaki Y, Terasaki M, Kanazawa S, Kokuho N, Urushiyama H, Kajimoto Y, Kunugi S, Maruyama M, Akimoto T, Miura Y, Igarashi T, Ohsawa I, Shimizu A. · Journal of cellular and molecular medicine. 2019;23(10):7043-7053.
Study at a glance
Preclinical
mouse, mice, rabbit, cell used to study respiratory health.
Full text reports an injected or infused H₂ intervention. Detected intervention quantities or schedules: 10 months. · H₂-related quantities reported in the intervention passages: 10 months. Values are not combined across different experimental arms.
10 months
Article-reported result excerpt (24 words maximum): “H_2 treatment protected against lung damage as evidenced by a reversal of the increases in serum SP‐D levels (Figure [3]K) and lung density on…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Respiratory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mouse, mice, rabbit, cell used to study respiratory health.
Preclinical study; group or assay counts reported in the full text include n=20, n=6, n=5, n=9, n=8.
10 months
Full text reports an injected or infused H₂ intervention. Detected intervention quantities or schedules: 10 months.
an injected or infused H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 10 months. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “H_2 treatment protected against lung damage as evidenced by a reversal of the increases in serum SP‐D levels (Figure [3]K) and lung density on…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 31424157 · DOI: 10.1111/jcmm.14603
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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