Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
Chen J, Mu F, Lu T, Du D, Xu K. · OncoTargets and therapy. 2019;12:11145-11151.
What kind of evidence is this?
Human
Case report
Respiratory health
Inhaled H₂
Not reported in this record.
Not reported in this record.
Methods at a glance
Human participants studied for respiratory health. See eligibility criteria in the linked full text.
Human study; the article does not state one consolidated sample total, so no total is inferred.
6 hrs
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 6 hrs, 4 months, 3 L/min, 67%, 33%.
Brown’s gas / oxyhydrogen — H₂ and O₂ co-delivered, not H₂ alone.
H₂-related quantities reported in the intervention passages: 6 hrs, 4 months, 3 L/min, 67%, 33%. Values are not combined across different experimental arms.
2010 mL/min H₂, calculated from 67% H₂ and 3000 mL/min total flow reported in the full text.
33% O₂; 990 mL/min O₂ calculated from the reported total flow.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “There were increased levels of carcinoembryonic antigen (CEA, 29.44 ng/mL), carbohydrate antigen-125 (CA125, 153 U/mL) and cytokeratin fragment antigen21-1 (CYFRA21-1, 12.1 ng/mL) before the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Human evidence; design, sample size and comparator limit interpretation. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies only to the population and protocol reported in this respiratory health article.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 31908482 · DOI: 10.2147/ott.s235195
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10