Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
Yang Y, Liu PY, Bao W, Chen SJ, Wu FS, Zhu PY. · 2020.
Study at a glance
Preclinical
Human endometrial-cancer cell lines and a mouse tumor model.
Hydrogenated culture medium and hydrogen-water exposure in the animal protocol. · Approximately 1.0 ppm in the hydrogenated medium/water under the reported preparation.
Article-specific cell exposures and 24-day animal follow-up.
Hydrogen exposure was reported to reduce tumor growth and alter pyroptosis-related markers in the tested cell and mouse models.
Preclinical evidence only; pathway experiments and multiple laboratory endpoints do not establish clinical efficacy.
What kind of evidence is this?
Preclinical
Controlled endometrial-cancer cell and mouse study
Cancer research
Other forms
Positive preclinical signal.
Tumor-growth and mechanistic cell-death outcomes.
Methods
Human endometrial-cancer cell lines and a mouse tumor model.
Cell assays and small animal groups; assay-specific counts are reported.
Article-specific cell exposures and 24-day animal follow-up.
Hydrogenated culture medium and hydrogen-water exposure in the animal protocol.
H₂ dissolved in culture medium or water.
Approximately 1.0 ppm in the hydrogenated medium/water under the reported preparation.
Conventional medium/water and mechanistic inhibitor comparisons.
Outcomes and reported result
Cell viability, tumor growth, pyroptosis and NLRP3/caspase-1/GSDMD signaling.
Hydrogen exposure was reported to reduce tumor growth and alter pyroptosis-related markers in the tested cell and mouse models.
The full article was checked for methods, intervention details, outcomes, positive and null findings, funding and conflicts. This record does not imply medical efficacy.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; pathway experiments and multiple laboratory endpoints do not establish clinical efficacy.
The reported endometrial-cancer cell and mouse models only.
SYRCLE animal-study tool — preliminary
Some concerns
Controlled experiments were used, but allocation concealment, blinded assessment and multiplicity handling were unclear.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 31924176 · DOI: 10.1186/s12885-019-6491-6
A free full article is available through PubMed Central.
Official PubMed Central full article and PubMed bibliographic record; source identity, methods, intervention, results, funding and conflicts checked 10 August 2026.
10 August 2026
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