Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial
Maruyama T, Takayama E, Tokuno S, Morita M, Ekuni D. · Healthcare (Basel, Switzerland). 2025;13(5):577.
Study at a glance
Human
Human participants studied for cancer research. See eligibility criteria in the linked full text.
Full text reports an oral H₂-generating preparation. Detected intervention quantities or schedules: 40 ppm, 60 days. · H₂-related quantities reported in the intervention passages: 40 ppm, 60 days. Values are not combined across different experimental arms.
60 days
Article-reported result excerpt (24 words maximum): “Conclusions : Administration of hydrogen-rich jelly for 14 days decreased gingival inflammation.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Human
Human interventional or observational study
Cancer research
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for cancer research. See eligibility criteria in the linked full text.
Human study; the article does not state one consolidated sample total, so no total is inferred.
60 days
Full text reports an oral H₂-generating preparation. Detected intervention quantities or schedules: 40 ppm, 60 days.
an oral H₂-generating preparation — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 40 ppm, 60 days. Values are not combined across different experimental arms.
Placebo or matched control reported in the full article.
Outcomes and reported result
tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers
Article-reported result excerpt (24 words maximum): “Conclusions : Administration of hydrogen-rich jelly for 14 days decreased gingival inflammation.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies only to the population and protocol reported in this cancer research article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 40077138 · DOI: 10.3390/healthcare13050577
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.