Pharmacokinetics of a single inhalation of hydrogen gas in pigs
Sano M, Ichihara G, Katsumata Y, Hiraide T, Hirai A, Momoi M, Tamura T, Ohata S, Kobayashi E. · PloS one. 2020;15(6):e0234626.
Study at a glance
Preclinical
pigs, pig used to study cardiovascular and circulatory health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1 mL, 100%, 0.2 mL, 0.4 mL, 130 ppm. · H₂-related quantities reported in the intervention passages: 1 mL, 100%, 0.2 mL, 0.4 mL, 130 ppm. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “These results indicate that H_2 produced by bacteria in the colon is carried by the portal circulation, most of it is trapped in the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Cardiovascular and circulatory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
pigs, pig used to study cardiovascular and circulatory health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
Multiple article-specific time points; see the linked full methods.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1 mL, 100%, 0.2 mL, 0.4 mL, 130 ppm.
Inhaled molecular H₂ at 100%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 1 mL, 100%, 0.2 mL, 0.4 mL, 130 ppm. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Placebo or matched control reported in the full article.
Outcomes and reported result
inflammation and cytokines, neurological or behavioral measures, cardiovascular measures, respiratory measures
Article-reported result excerpt (24 words maximum): “These results indicate that H_2 produced by bacteria in the colon is carried by the portal circulation, most of it is trapped in the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 32559239 · DOI: 10.1371/journal.pone.0234626
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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