Pharmacokinetics of a single inhalation of hydrogen gas in pigs
Sano M, Ichihara G, Katsumata Y, Hiraide T, Hirai A, Momoi M, Tamura T, Ohata S, Kobayashi E. · PloS one. 2020;15(6):e0234626.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Cardiovascular and circulatory health
Inhaled H₂
Not reported in this record.
Not reported in this record.
Methods at a glance
pigs, pig used to study cardiovascular and circulatory health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
Multiple article-specific time points; see the linked full methods.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1 mL, 100%, 0.2 mL, 0.4 mL, 130 ppm.
Inhaled molecular H₂ at 100%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 1 mL, 100%, 0.2 mL, 0.4 mL, 130 ppm. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Placebo or matched control reported in the full article.
Outcomes and reported result
inflammation and cytokines, neurological or behavioral measures, cardiovascular measures, respiratory measures
Article-reported result excerpt (24 words maximum): “These results indicate that H_2 produced by bacteria in the colon is carried by the portal circulation, most of it is trapped in the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 32559239 · DOI: 10.1371/journal.pone.0234626
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10