Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF- κ B/NLRP3 Pathway
Yang L, Guo Y, Fan X, Chen Y, Yang B, Liu KX, Liu KX, Zhou J. · Mediators of inflammation. 2020;2020:4359305.
Study at a glance
Preclinical
rats, tissue, tissues, cells used to study cardiovascular and circulatory health.
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 10 mL/kg, 20 mL/kg, 0.6 mmol/L, 0.6 ppm, 10 min, 1%, 0.9%. · H₂-related quantities reported in the intervention passages: 10 mL/kg, 20 mL/kg, 0.6 mmol/L, 0.6 ppm, 10 min, 1%, 0.9%. Values are not combined across different experimental arms.
10 min
Article-reported result excerpt (24 words maximum): “As illustrated in [Figure 1], the survival rate at 24 h was significantly reduced in rats subjected to an intestinal I/R event (13.33%, 2…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, tissue, tissues, cells used to study cardiovascular and circulatory health.
Preclinical study; the full text reports 15 rats, with group/assay counts including n=39.
10 min
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 10 mL/kg, 20 mL/kg, 0.6 mmol/L, 0.6 ppm, 10 min, 1%, 0.9%.
H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 10 mL/kg, 20 mL/kg, 0.6 mmol/L, 0.6 ppm, 10 min, 1%, 0.9%. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “As illustrated in [Figure 1], the survival rate at 24 h was significantly reduced in rats subjected to an intestinal I/R event (13.33%, 2…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 32587471 · DOI: 10.1155/2020/4359305
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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