Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model
Tamura T, Sano M, Matsuoka T, Yoshizawa J, Yamamoto R, Katsumata Y, Endo J, Homma K, Kajimura M, Suzuki M, Kobayashi E, Sasaki J. · Shock (Augusta, Ga.). 2020;54(3):377-385.
Study at a glance
Preclinical
rats, cells used to study cardiovascular and circulatory health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 30 min, 26%, 74%, 1.3%, 72.7%. · H₂-related quantities reported in the intervention passages: 30 min, 26%, 74%, 1.3%, 72.7%. Values are not combined across different experimental arms.
30 min
Article-reported result excerpt (24 words maximum): “B, H_2 inhalation reduced IL-1β but this reduction was not significant ( P = 0.09).” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Randomized controlled study
Cardiovascular and circulatory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, cells used to study cardiovascular and circulatory health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
30 min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 30 min, 26%, 74%, 1.3%, 72.7%.
Inhaled molecular H₂ at 1.3%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 30 min, 26%, 74%, 1.3%, 72.7%. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
26% O₂ reported; total flow is absent, so O₂ flow in mL/min cannot be calculated.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “B, H_2 inhalation reduced IL-1β but this reduction was not significant ( P = 0.09).” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 32804466 · DOI: 10.1097/shk.0000000000001459
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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