Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome
Tamura T et al. · J Clin Biochem Nutr. 2020;67(2):214–221.
Study at a glance
Human
Comatose adults after non-traumatic out-of-hospital cardiac arrest receiving targeted temperature management
2% H₂ delivered through a ventilator with titrated oxygen from ICU admission · 2% H₂ by volume; inspired oxygen was titrated clinically.
18 hours
Markers varied among the five patients. The authors explicitly judged the effect on oxidative stress and cytokines indefinite because of methodological weaknesses.
Only five patients, no control group, heterogeneous arrest causes and simultaneous targeted temperature management. Several authors received research funding from the gas supplier Taiyo Nippon Sanso.
What kind of evidence is this?
Human
Single-center open-label single-arm prospective substudy
Critical care and ischemia-reperfusion
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Comatose adults after non-traumatic out-of-hospital cardiac arrest receiving targeted temperature management
5 participants: 4 cardiogenic arrests and 1 septic arrest
18 hours
2% H₂ delivered through a ventilator with titrated oxygen from ICU admission
H₂ added to ventilator gas with clinically titrated O₂ — not Brown’s gas.
2% H₂ by volume; inspired oxygen was titrated clinically.
No concurrent control group
Outcomes and reported result
Arterial H₂, plasma and urine oxidative-stress markers, IL-6 and TNF-α
Markers varied among the five patients. The authors explicitly judged the effect on oxidative stress and cytokines indefinite because of methodological weaknesses.
Methods, full results, funding and conflicts checked in the free full text; independent appraisal remains incomplete.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Only five patients, no control group, heterogeneous arrest causes and simultaneous targeted temperature management. Several authors received research funding from the gas supplier Taiyo Nippon Sanso.
Comatose post-cardiac-arrest patients receiving intensive-care ventilation and targeted temperature management.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 33041520 · DOI: 10.3164/jcbn.19-101
Open-access full text is available through PMC.
Open-access PMC full text and PubMed bibliographic record.
10 August 2026
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