Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway
Ke H, Liu D, Li T, Chu X, Xin D, Han M, Wang S, Wang Z. · Drug design, development and therapy. 2020;14:3827-3839.
Study at a glance
Preclinical
mice, tissue, cells, cell used to study other neurological conditions.
Full text reports H₂ dissolved in saline. No numeric quantity is inferred beyond the source wording. · The full article describes the H₂ intervention but does not report a numeric H₂ concentration.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “As shown in [Figure 1], levels of p-Akt at 72 h post-HI were decreased in the HI versus the Sham group [F(3,8)=29.835, p <…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Other neurological conditions
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, tissue, cells, cell used to study other neurological conditions.
Preclinical study; group or assay counts reported in the full text include n=5, n=4, n=3, n=11, n=8, n=34.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in saline. No numeric quantity is inferred beyond the source wording.
H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
The full article describes the H₂ intervention but does not report a numeric H₂ concentration.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “As shown in [Figure 1], levels of p-Akt at 72 h post-HI were decreased in the HI versus the Sham group [F(3,8)=29.835, p <…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 33061290 · DOI: 10.2147/dddt.s264684
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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