Electrolytic hydrogen-generating bottle supplies drinking water with free/combined chlorine and ozone repressed within safety standard under hydrogen-rich conditions
Hatae T, Miwa N. · Medical Gas Research. 2021;11(2):61–65.
Study at a glance
Preclinical
Osaka municipal tap water electrolyzed in commercial bottle-type H₂-water generators; no animals or people were exposed.
Direct-current electrolysis of 165–330 mL tap water for 10–30 minutes in named household devices. · The focal bottle produced 444±7.2 μg/L dissolved H₂ after 10 minutes and a mean 479.3±79.1 μg/L after 30 minutes; gas generation flow was not provided.
Ten to thirty minutes of electrolysis followed by immediate water-chemistry measurement.
The focal device increased dissolved H₂ while measured residual chlorine remained far below the cited 5 mg/L WHO value and ozone was below the reported 0.05 mg/L detection limit. Some other bottles showed time-dependent chlorine readings but still below the cited limit. No biological toxicity, consumption or health outcome was tested.
Bench chemistry only, small repeats, selected commercial devices, no comprehensive contaminant analysis, no biological safety assessment and broad health language unsupported by this experiment. Authors reported no funding and no conflict.
What kind of evidence is this?
Preclinical
Bench comparison of household electrolysis bottles and water-chemistry measurements
Other molecular hydrogen research
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Osaka municipal tap water electrolyzed in commercial bottle-type H₂-water generators; no animals or people were exposed.
Repeated measurements (reported n=4–12, in two to four experimental repeats) across full/half volumes, times and devices.
Ten to thirty minutes of electrolysis followed by immediate water-chemistry measurement.
Direct-current electrolysis of 165–330 mL tap water for 10–30 minutes in named household devices.
H₂ dissolved in electrolyzed drinking water; the evolved-gas H₂/O₂ composition was not reported, so it is not labeled Brown's gas and was not inhaled.
The focal bottle produced 444±7.2 μg/L dissolved H₂ after 10 minutes and a mean 479.3±79.1 μg/L after 30 minutes; gas generation flow was not provided.
Tap water before electrolysis and several commercial electrolyzer bottles; measurements used multiple chlorine/ozone methods.
Outcomes and reported result
Dissolved H₂, ORP, free/combined/total residual chlorine and dissolved ozone.
The focal device increased dissolved H₂ while measured residual chlorine remained far below the cited 5 mg/L WHO value and ozone was below the reported 0.05 mg/L detection limit. Some other bottles showed time-dependent chlorine readings but still below the cited limit. No biological toxicity, consumption or health outcome was tested.
The complete free PMC article, methods, tables/figures and disclosures were checked for device names, water volumes, dissolved concentration, missing flow/gas composition, chlorine/ozone findings, replication, funding and conflicts.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Bench chemistry only, small repeats, selected commercial devices, no comprehensive contaminant analysis, no biological safety assessment and broad health language unsupported by this experiment. Authors reported no funding and no conflict.
Water-generator chemistry under the tested tap-water conditions; it does not prove that a device or its water is clinically beneficial or comprehensively safe.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 33818445 · DOI: 10.4103/2045-9912.311496
Free full article in PubMed Central.
Complete PMC article and PubMed metadata; full-text extraction checked 9 August 2026.
10 August 2026
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