Inhalation of Molecular Hydrogen, a Rescue Treatment for Noise-Induced Hearing Loss
Fransson AE, Videhult Pierre P, Risling M, Laurell GFE. · Frontiers in cellular neuroscience. 2021;15:658662.
Study at a glance
Preclinical
guinea pigs, cell, cells, tissues used to study other neurological conditions.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1 week, 2 weeks, 0.3%, 10 min, 45 min, 12 mm. · H₂-related quantities reported in the intervention passages: 1 week, 2 weeks, 0.3%, 10 min, 45 min, 12 mm. Values are not combined across different experimental arms.
1 week
Article-reported result excerpt (24 words maximum): “Compared with the pre-measurements, both the Acute + H_2 and Acute + Air groups demonstrated significant threshold shifts of approximately 50–60 dB at all…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Other neurological conditions
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
guinea pigs, cell, cells, tissues used to study other neurological conditions.
Preclinical study; group or assay counts reported in the full text include n=8.
1 week
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1 week, 2 weeks, 0.3%, 10 min, 45 min, 12 mm.
Inhaled molecular H₂; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 1 week, 2 weeks, 0.3%, 10 min, 45 min, 12 mm. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “Compared with the pre-measurements, both the Acute + H_2 and Acute + Air groups demonstrated significant threshold shifts of approximately 50–60 dB at all…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 34140880 · DOI: 10.3389/fncel.2021.658662
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.