Hydrogen gas post-conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoK_ATP signaling pathway
Zhang CS, Han Q, Song ZW, Jia HY, Shao TP, Chen YP. · Experimental and therapeutic medicine. 2021;22(2):836.
Study at a glance
Preclinical
rats, rat, tissues, tissue used to study other neurological conditions.
Full text reports H₂-containing gas exposure plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 2.9%, 20%, 1 l/min, 8%, 10%. · H₂-related quantities reported in the intervention passages: 2.9%, 20%, 1 l/min, 8%, 10%. Values are not combined across different experimental arms.
1 l/min
Article-reported result excerpt (24 words maximum): “Hydrogen gas post-conditioning after SAH induction significantly improved the neurobehavioral score in rats compared with that in rats treated with SAH alone 24 h…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Other neurological conditions
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, rat, tissues, tissue used to study other neurological conditions.
Preclinical study; the full text reports 5 rats, with group/assay counts including n=24, n=30, n=25, n=31, n=27, n=6.
1 l/min
Full text reports H₂-containing gas exposure plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 2.9%, 20%, 1 l/min, 8%, 10%.
Molecular H₂ gas exposure at 2.9%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 2.9%, 20%, 1 l/min, 8%, 10%. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “Hydrogen gas post-conditioning after SAH induction significantly improved the neurobehavioral score in rats compared with that in rats treated with SAH alone 24 h…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 34149882 · DOI: 10.3892/etm.2021.10268
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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