Hydrogen gas post-conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoK_ATP signaling pathway
Zhang CS, Han Q, Song ZW, Jia HY, Shao TP, Chen YP. · Experimental and therapeutic medicine. 2021;22(2):836.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Other neurological conditions
Other forms
Not reported in this record.
Not reported in this record.
Methods at a glance
rats, rat, tissues, tissue used to study other neurological conditions.
Preclinical study; the full text reports 5 rats, with group/assay counts including n=24, n=30, n=25, n=31, n=27, n=6.
1 l/min
Full text reports H₂-containing gas exposure plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 2.9%, 20%, 1 l/min, 8%, 10%.
Molecular H₂ gas exposure at 2.9%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 2.9%, 20%, 1 l/min, 8%, 10%. Values are not combined across different experimental arms.
29 mL/min H₂, calculated from 2.9% H₂ and 1000 mL/min total flow reported in the full text.
20% O₂; 200 mL/min O₂ calculated from the reported total flow.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “Hydrogen gas post-conditioning after SAH induction significantly improved the neurobehavioral score in rats compared with that in rats treated with SAH alone 24 h…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 34149882 · DOI: 10.3892/etm.2021.10268
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10