Hydrogen gas post-conditioning alleviates cognitive dysfunction and anxiety-like behavior in a rat model of subarachnoid hemorrhage
Song JH, Jia HY, Shao TP, Liu ZB, Zhao YP. · Experimental and therapeutic medicine. 2021;22(4):1121.
Study at a glance
Preclinical
rats, rat, tissue, cell used to study cardiovascular and circulatory health.
Full text reports H₂-containing gas exposure. Detected intervention quantities or schedules: 2.9%, 20%, 1 l/min, 99%, 3%, 35 min, 40%. · H₂-related quantities reported in the intervention passages: 2.9%, 20%, 1 l/min, 99%, 3%, 35 min, 40%. Values are not combined across different experimental arms.
1 l/min
Article-reported result excerpt (24 words maximum): “2C]) demonstrated that the vmPFC perfusion in SAH and SAH + H_2 groups was significantly reduced (vs. sham, P<0.05; [Fig.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, rat, tissue, cell used to study cardiovascular and circulatory health.
Preclinical study; the full text reports 108 rats, with group/assay counts including n=108, n=36, n=6.
1 l/min
Full text reports H₂-containing gas exposure. Detected intervention quantities or schedules: 2.9%, 20%, 1 l/min, 99%, 3%, 35 min, 40%.
Molecular H₂ gas exposure at 2.9%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 2.9%, 20%, 1 l/min, 99%, 3%, 35 min, 40%. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, neurological or behavioral measures, cardiovascular measures
Article-reported result excerpt (24 words maximum): “2C]) demonstrated that the vmPFC perfusion in SAH and SAH + H_2 groups was significantly reduced (vs. sham, P<0.05; [Fig.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 34504575 · DOI: 10.3892/etm.2021.10555
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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