The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration
Liang IC, Ko WC, Hsu YJ, Lin YR, Chang YH, Zong XH, Lai PC, Chang DC, Hung CF. · International journal of molecular sciences. 2021;22(21):12049.
Study at a glance
Preclinical
mice, mouse, cell, rabbit used to study cardiovascular and circulatory health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 67%, 33%, 3 L/min, 21%, 42%, 37%. · H₂-related quantities reported in the intervention passages: 67%, 33%, 3 L/min, 21%, 42%, 37%. Values are not combined across different experimental arms.
3 L/min
Article-reported result excerpt (24 words maximum): “The effect was similar between the 2.5 h/2.5 h and 5 h groups and showed to be less effective in the 2 h group.…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Randomized controlled study
Cardiovascular and circulatory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, mouse, cell, rabbit used to study cardiovascular and circulatory health.
Preclinical study; group or assay counts reported in the full text include n=3.
3 L/min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 67%, 33%, 3 L/min, 21%, 42%, 37%.
Inhaled molecular H₂ at 67%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 67%, 33%, 3 L/min, 21%, 42%, 37%. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
33% O₂ reported; total flow is absent, so O₂ flow in mL/min cannot be calculated.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “The effect was similar between the 2.5 h/2.5 h and 5 h groups and showed to be less effective in the 2 h group.…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 34769482 · DOI: 10.3390/ijms222112049
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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