Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs
Ichihara G, Katsumata Y, Moriyama H, Kitakata H, Hirai A, Momoi M, Ko S, Shinya Y, Kinouchi K, Kobayashi E, Sano M. · Heliyon. 2021;7(11):e08359.
Study at a glance
Preclinical
pigs, pig used to study metabolic and lipid health.
Full text reports H₂ dissolved in another reported solution plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 1 mL, 1.5 mm, 500 mL, 2 min, 340%. · H₂-related quantities reported in the intervention passages: 1 mL, 1.5 mm, 500 mL, 2 min, 340%. Values are not combined across different experimental arms.
2 min
Article-reported result excerpt (24 words maximum): “In the two pigs injected with H_2-rich glucose solution and one of the pigs injected with H_2-free glucose solution, the respective glucose concentrations in…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Metabolic and lipid health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
pigs, pig used to study metabolic and lipid health.
Preclinical study; group or assay counts reported in the full text include n=2.
2 min
Full text reports H₂ dissolved in another reported solution plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 1 mL, 1.5 mm, 500 mL, 2 min, 340%.
H₂ dissolved in another reported solution plus an injected or infused H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 1 mL, 1.5 mm, 500 mL, 2 min, 340%. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “In the two pigs injected with H_2-rich glucose solution and one of the pigs injected with H_2-free glucose solution, the respective glucose concentrations in…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 34816046 · DOI: 10.1016/j.heliyon.2021.e08359
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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