Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model
Jeong ES, Bajgai J, You IS, Rahman MH, Fadriquela A, Sharma S, Kwon HU, Lee SY, Kim CS, Lee KJ. · International journal of molecular sciences. 2021;22(24):13313.
Study at a glance
Preclinical
mice, tissue, mouse, rat used to study cardiovascular and circulatory health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 10 days, 175 mm, 2%, 30 min. · H₂-related quantities reported in the intervention passages: 10 days, 175 mm, 2%, 30 min. Values are not combined across different experimental arms.
10 days
Article-reported result excerpt (24 words maximum): “Likewise, administration of H_2 also significantly decreased seizure-like behaviors in TMT-induced mice from day 2 ( p < 0.05), day 3 ( p <…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Cardiovascular and circulatory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, tissue, mouse, rat used to study cardiovascular and circulatory health.
Preclinical study; the full text reports 6 mice, with group/assay counts including n=6.
10 days
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 10 days, 175 mm, 2%, 30 min.
Inhaled molecular H₂ at 2%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 10 days, 175 mm, 2%, 30 min. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “Likewise, administration of H_2 also significantly decreased seizure-like behaviors in TMT-induced mice from day 2 ( p < 0.05), day 3 ( p <…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 34948107 · DOI: 10.3390/ijms222413313
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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