The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial
Jin L, Fan K, Tan S, Liu S, Ge Q, Wang Y, Ai Z, Yu S. · Journal of inflammation research. 2022;15:3983-3995.
Study at a glance
Human
Human participants studied for immune and inflammatory conditions. See eligibility criteria in the linked full text.
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 0.6mmol/l, 90%, 5%, 4 weeks, 100mL. · H₂-related quantities reported in the intervention passages: 0.6mmol/l, 90%, 5%, 4 weeks, 100mL. Values are not combined across different experimental arms.
4 weeks
Article-reported result excerpt (24 words maximum): “There were no significant differences between the two groups at baseline, such as gender, age, course of the disease, allergy history, pre-medication symptoms, and…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Randomized blinded controlled study
Immune and inflammatory conditions
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for immune and inflammatory conditions. See eligibility criteria in the linked full text.
Human study; the full text reports 128 patients, with group/assay counts including n=52, n=51.
4 weeks
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 0.6mmol/l, 90%, 5%, 4 weeks, 100mL.
H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.6mmol/l, 90%, 5%, 4 weeks, 100mL. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, metabolic laboratory measures, cardiovascular measures, respiratory measures
Article-reported result excerpt (24 words maximum): “There were no significant differences between the two groups at baseline, such as gender, age, course of the disease, allergy history, pre-medication symptoms, and…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this immune and inflammatory conditions article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 35873384 · DOI: 10.2147/jir.s365611
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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