Molecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4/NF-κB Inflammatory Pathway
Yang WC, Li TT, Wan Q, Zhang X, Sun LY, Zhang YR, Lai PC, Li WZ. · Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023;18(1-2):90-99.
Study at a glance
Preclinical
rats, cells, rat, tissue used to study metabolic and lipid health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 60 min, 20 min, 3.0 L/min, 42%, 21%, 37%. · H₂-related quantities reported in the intervention passages: 60 min, 20 min, 3.0 L/min, 42%, 21%, 37%. Values are not combined across different experimental arms.
60 min
Article-reported result excerpt (24 words maximum): “Compared with rats in group M (52.9%), molecular hydrogen treatment induced significant survival benefits, group H (80%) and group HN (77.8%) survived to the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Metabolic and lipid health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, cells, rat, tissue used to study metabolic and lipid health.
Preclinical study; group or assay counts reported in the full text include n=30, n=18, n=12, n=6.
60 min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 60 min, 20 min, 3.0 L/min, 42%, 21%, 37%.
Inhaled molecular H₂ at 42%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 60 min, 20 min, 3.0 L/min, 42%, 21%, 37%. Values are not combined across different experimental arms.
1260 mL/min H₂, calculated from 42% H₂ and 3000 mL/min total flow reported in the full text.
21% O₂; 630 mL/min O₂ calculated from the reported total flow.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, inflammation and cytokines, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “Compared with rats in group M (52.9%), molecular hydrogen treatment induced significant survival benefits, group H (80%) and group HN (77.8%) survived to the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 35895245 · DOI: 10.1007/s11481-022-10051-w
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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