The effects of hydrogen treatment in a cigarette smoke solution-induced chronic obstructive pulmonary disease-like changes in an animal model
Yang HJ, Tsou WH, Shen MC, Liu CY, Saunders HM, Wang KY, Douglas FL. · Journal of thoracic disease. 2022;14(11):4246-4255.
Study at a glance
Preclinical
mice, mouse, cell used to study respiratory health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 42%, 21%, 43%, 0.9 L/min, 75 minutes, 63 days. · H₂-related quantities reported in the intervention passages: 42%, 21%, 43%, 0.9 L/min, 75 minutes, 63 days. Values are not combined across different experimental arms.
0.9 L/min
Article-reported result excerpt (24 words maximum): “The MLI of the lung in the COPD + H_2/O_2 group (36.254±7.487) was significantly decreased compared to the COPD group (52.068±16.473) (P<0.05, [ Figure…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Respiratory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, mouse, cell used to study respiratory health.
Preclinical study; group or assay counts reported in the full text include n=8, n=10, n=12, n=6, n=4.
0.9 L/min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 42%, 21%, 43%, 0.9 L/min, 75 minutes, 63 days.
Inhaled molecular H₂ at 42%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 42%, 21%, 43%, 0.9 L/min, 75 minutes, 63 days. Values are not combined across different experimental arms.
378 mL/min H₂, calculated from 42% H₂ and 900 mL/min total flow reported in the full text.
21% O₂; 189 mL/min O₂ calculated from the reported total flow.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, respiratory measures
Article-reported result excerpt (24 words maximum): “The MLI of the lung in the COPD + H_2/O_2 group (36.254±7.487) was significantly decreased compared to the COPD group (52.068±16.473) (P<0.05, [ Figure…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36524091 · DOI: 10.21037/jtd-22-324
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.