Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients
Lin H, Du J, Tian Z, Yu Y, Cui Y, Xie K. · Journal of personalized medicine. 2022;13(1):67.
Study at a glance
Human
Human participants studied for other neurological conditions. See eligibility criteria in the linked full text.
Full text reports H₂-containing gas exposure. Detected intervention quantities or schedules: 33.3%, 60 min, 3 L/min, 66.7%, 90%. · H₂-related quantities reported in the intervention passages: 33.3%, 60 min, 3 L/min, 66.7%, 90%. Values are not combined across different experimental arms.
60 min
Article-reported result excerpt (24 words maximum): “In our preliminary experiment, the incidence of delirium was reduced by 40% when hydrogen was used for surgery patients.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Randomized blinded controlled study
Other neurological conditions
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for other neurological conditions. See eligibility criteria in the linked full text.
Human study; the full text reports 170 patients, with group/assay counts including n=85, n=70, n=83.
60 min
Full text reports H₂-containing gas exposure. Detected intervention quantities or schedules: 33.3%, 60 min, 3 L/min, 66.7%, 90%.
Brown’s gas / oxyhydrogen — H₂ and O₂ co-delivered, not H₂ alone.
H₂-related quantities reported in the intervention passages: 33.3%, 60 min, 3 L/min, 66.7%, 90%. Values are not combined across different experimental arms.
Placebo or matched control reported in the full article.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “In our preliminary experiment, the incidence of delirium was reduced by 40% when hydrogen was used for surgery patients.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this other neurological conditions article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36675728 · DOI: 10.3390/jpm13010067
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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