Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients
Lin H, Du J, Tian Z, Yu Y, Cui Y, Xie K. · Journal of personalized medicine. 2022;13(1):67.
What kind of evidence is this?
Human
Randomized blinded controlled study
Other neurological conditions
Other forms
Not reported in this record.
Not reported in this record.
Methods at a glance
Human participants studied for other neurological conditions. See eligibility criteria in the linked full text.
Human study; the full text reports 170 patients, with group/assay counts including n=85, n=70, n=83.
60 min
Full text reports H₂-containing gas exposure. Detected intervention quantities or schedules: 33.3%, 60 min, 3 L/min, 66.7%, 90%.
Brown’s gas / oxyhydrogen — H₂ and O₂ co-delivered, not H₂ alone.
H₂-related quantities reported in the intervention passages: 33.3%, 60 min, 3 L/min, 66.7%, 90%. Values are not combined across different experimental arms.
2001 mL/min H₂, calculated from 66.7% H₂ and 3000 mL/min total flow reported in the full text.
33.3% O₂; 999 mL/min O₂ calculated from the reported total flow.
Placebo or matched control reported in the full article.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “In our preliminary experiment, the incidence of delirium was reduced by 40% when hydrogen was used for surgery patients.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Human evidence; design, sample size and comparator limit interpretation. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies only to the population and protocol reported in this other neurological conditions article.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 36675728 · DOI: 10.3390/jpm13010067
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10