Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
Ono H, Nishijima Y, Ohta S. · Pharmaceuticals (Basel, Switzerland). 2023;16(3):434.
Study at a glance
Human
Human participants studied for other neurological conditions. See eligibility criteria in the linked full text.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 6 months, 3%, 1 week. · H₂-related quantities reported in the intervention passages: 6 months, 3%, 1 week. Values are not combined across different experimental arms.
6 months
Article-reported result excerpt (24 words maximum): “The mean value of the neuron tracts significantly increased with 6-month H_2 inhalation vs. the control (*** p = 0.001) and vs. the initial…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Human
Randomized blinded controlled study
Other neurological conditions
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for other neurological conditions. See eligibility criteria in the linked full text.
Human study; the full text reports 19 patients.
6 months
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 6 months, 3%, 1 week.
Inhaled molecular H₂ at 3%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 6 months, 3%, 1 week. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “The mean value of the neuron tracts significantly increased with 6-month H_2 inhalation vs. the control (*** p = 0.001) and vs. the initial…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies only to the population and protocol reported in this other neurological conditions article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36986533 · DOI: 10.3390/ph16030434
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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